舌下含服粉尘螨滴剂治疗儿童过敏性鼻炎依从性及安全性的临床观察

Clinical investigation of dermatophagoides farinae drops by sublingual medication in treating children with allergic rhinitis

目的观察舌下免疫治疗在变应性鼻炎患儿中的疗效、安全性及依从性。方法选择80例对尘螨过敏的变应性鼻炎患儿，随机分成实验组和对照组各40例，分别予舌下含服粉尘螨滴剂和皮下注射屋尘螨变应原进行脱敏治疗1年。比较2组患儿用药前后症状评分的情况以及2种治疗方法的安全性和依从性。结果2组患儿治疗后的症状评分较治疗前有显著改善，2组患儿不良反应发生率及治疗依从性比较无显著差异。结论舌下含服粉尘螨滴剂对儿童变应性鼻炎具有较好的治疗作用。粉尘螨滴剂作为一种新的国产脱敏药物其疗效可以与国外皮下注射疫苗相媲美，为我国过敏性鼻炎患儿又增加了一种药物的选择。

Objective To study the clinical efficacy,safety and compliance of specific sublingual immunotherapy in allergic rhinitis children： Methods 80 cases of children with allergic rhinitis were ran- domly divided into the experimental group and the control group with 30 patients in each.The experimental group received dermatophagoides farinae drops by sublingual medication and the control group received standardization allergen vaccine of dermatophagoides pteronyssinus by subcutaneous injection. The observing time lasted 12 months. Clinic symptoms score before and after treatment,safety and compliance between two groups were compared. Results The clinic symptoms score after treatment in both groups were significantly decreased. There was obvious difference between two groups in the incidence of adverse reactions and treatment compliance. Conclusions Sublingual immunotherapy by dermatophagoides farinae drops is effective and comparable to subcutaneous injection therapy by allergen vaccine. It may be a new choice for children with allergy disease.