多药耐药基因1与肝癌

Relationship between multi-drug resistance 1 gene and hepatocellular carcinoma

目前认为肝癌化疗失败的主要原因与多药耐药有关,而多药耐药基因1(Multi-drugresistance 1 gene,mdr1)编码的P-gp蛋白(Permeability-glycoprotein)被认为可能是参与肿瘤多药耐药的主要因素之一。目前的研究发现,mdr1参与肝癌的多药耐药可能与多种机制有关,而且mdr1还可能与肝癌的血管形成、肝癌细胞的凋亡有关;在逆转肝癌多药耐药的策略中,采用物理、药物、分子生物学方法、细胞因子等抑制或干扰mdr1的表达及P-gp蛋白的功能成为重要的方向。

In current knowledge,the main reason of the failure in the chemotherapy of hepatocellular carcinoma is due to multi-drug resistance,and the permeability glycoprotein（P-gp） coded by Multi-drug resistance 1 gene（mdr1） is supposed to be one of the main factors which lead to multi-drug resistance of tumors.Recent researches discover the relationship between mdr1 and multi-drug resistance of hepatocellular carcinoma maybe via several mechanisms,mdr1 also affects angiogenesis and apoptosis of hepatocellular carcinoma.It is becoming the important strategies in reversing multi-drug resistance of hepatocellular carcinoma to use physical ways,drugs,molecular biology technology and cell factors to inhibit/interfere the expression of mdr1 and the function of P-gp.