慢性淤胆型肝炎高压氧治疗前后肝组织学变化的观察

To observe the Changes in the Liver Tissue Structures of Patients with Choronic Cholestasis Hepatitis Treated with Hyperbaric Oxygenation

观察慢性淤胆型肝炎（ＣＣＨ） 高压氧（ＨＢＯ） 治疗前后肝组织学结构变化。用纯氧单仓治疗（２．５ ＭＰａ，２ｈ／ｄ，１０ｄ／ｃｙｃ，６ｃｙｃ）１０ 例ＣＣＨ，治疗前后肝穿，病理检查。９ 例肝细胞和毛细胆管淤胆减轻明显，７ 例肝细胞变性坏死，汇管区炎症减轻明显（ Ｐ＜ ０ ．０５） ；３ 例肝间质纤维化轻度减轻（ Ｐ＞ ０ ．０５） ；３ 例肝脏炎症及纤维化程度改善不明显。ＨＢＯ治疗ＣＣＨ 有较好的退黄和减轻肝脏组织结构损伤的作用。

To observe the changes in the liver tissue structures of patients with Chronic Cholestasis Hepatitis(CCH) treated with Hyperbaric Oxygenation(HBO).Ten patients were treated with HBO Dosage was 2.5Mpa,2 hours a day,10 days for one therapeutic course,with 2 days rest,altogether 6 courses.Before and after the treatment,the patients were done liver biopsy for the liver tissue,and were detected with ordinary pathology methods.9patients’ cholestasis were reduced in the liver cells and canaliculars,7 reducted in liver cell degeneration,necrosis and protal area inflammation;There was statistically significаnt(P<0.05).3 redced in liver fibrinoid regeneration,But there wasn’t statistically significnt(P>0.05).3 liver inflammation and fibrinoid regeneration wasn’t changed.HBO has good therapeutic effects on reducing the liver cholestasis and tissue structure injuries.