一氧化氮与高血压病患者病情的关系

Relationship between plasma nitric oxide level and severity of essential hypertension

目的 探讨一氧化氮（ＮＯ） 与高血压病患者病情的关系及临床意义。方法 检测５０ 例高血压病患者和３６例正常对照组血浆ＮＯ 浓度。结果 （１） 高血压病患者血浆ＮＯ 浓度较正常对照组明显地降低（ Ｐ ＜ ０－０１） ；（２） 高血压病患者血浆ＮＯ 浓度Ⅰ期最高，Ⅱ期居中，Ⅲ期最低，各期之间比较有极显著性差异（ Ｆ＝ ６７－５８ ，Ｐ＜ ０－０１） 。重度高血压病患者血浆ＮＯ 浓度明显地低于轻度、中度患者（ Ｐ ＜ ０－０１） ；中度高血压病患者血浆ＮＯ 浓度明显低于轻度（ Ｐ ＜ ０－０１） ；（３） 高血压病患者并发心力衰竭组血浆ＮＯ 浓度明显低于无心力衰竭组（ Ｐ ＜ ０－０１） 。结论 ＮＯ 参与高血压病的发生和发展，并与病情有关。检测血浆ＮＯ浓度可作为判断高血压病患者病情程度的指标。

Objective The relationship between plasma nitric oxide level and severity of essential hypertension and its clinical role was studied.Methods Plasma nitric oxide levels were measured in 50 patients with essential hypertension and in 36 normal controls.The results are as follows.Results (1)The nitrie oxide levels in hypertensive pafients were Nignificantey lower than that in normal controls(P<0.01).(2)The patients with stage Ⅰ hypertension had highest,those with stage Ⅱ hypertension had moderate and those with stage Ⅲ hypertension had lowest plasma nitric oxide levels.There was significant difference between the patients with different stages of hypertension(F=67.58,P<0.01).The level of nitric oxide in severe hypertensive patients was lower than those in mild and moderate hypertensive patients(P<0.01),and that in moderate hypertensive patients was lower than that in mild hypertensive patients(P<0.01).(3)The level of nitric oxide in hypertensive patients with heart failure was lower than that in those without heart failure(P< 0.01 ).Conclusions It is suggested that the level of plasma nitric oxide is relafed to the severity of essential hypertension.It might be used as an index to assess the severity of essential hypertension in clinical practice.