生脉、参附注射液对家兔休克复苏时血流动力学影响的对比研究

Influence of Shengmai Injection on Hemodynamics During Shock-Resuscitation in Rabbits A Comparison with Shenfu Injection

比较生脉注射液（SM）和参附注射液（SF）对失血性休克复苏时血流动力学的影响。采现失血性休克复苏家兔模型，分别于休克前、休克1小时、复苏1小时及2小时观察MAP（平均动脉压）、CO（心输出量）、SVR（外周血管阻力）、HR及CVP的变化，以及SM和SF对其影响。实验结果表明，休克复苏期间应用SM或SF均能显著升高MAP，增加CO，且显著降低SVR；休克复苏1小时，SM升高MAP及增加CO作用较SF强（P＜0．05），而复苏1小时及2小时，SF降低SVR作用较SM显著（P＜0．05），两药对HR及CVP影响无差异。提示休克复苏初期应用SM更能维持血流动力学稳定，而SF舒张血管作用强有利于改善组织灌注。

Objective: To compare the influence of Shengmai injection(SM) and Shenfu injection (SF) on hemodynamics during resuscitation of hemorrhagic shock.Methods: 28 rabbits were divided into control group (A, n = 6 ), shock-resuscitation group (B, n = 8 ), SF group (C, n= 7) and SM group (D, n= 7). The mean arterial pressure (MAP ), cardiac output (CO ), systemic vascular resistance (SVR ), heart rate (HR ) and central venous pressure (CVP) were measured before shock,after 1 hour of shock,and at 1, 2 hours after resuscitation. Results: SM and SF significantly increased MAP and CO, and decreased SVR during resuscitation. The increase of MAP and CO in group D were higher than those of group C at 1 hour after resuscitation (P< 0. 05 ), and there were on differences in CO and MAP between group C and group D at 2 hours after resuscitation. SVR in group C was lower than that of group D during resuscitation of shock (P< 0.05 ).The influence on HR and CVP of the two drugs had no difference. Conclusiou: SM is more effective in maintaining the stabilization of hemodycamics in the beginning of resuscitation, and SF has better effects in vascular dilatation and perfusion of tissues.