摘要
[目的]研究转化生长因子-β1Ⅱ型变体(TGF-β1RⅡ)在肝细胞癌蛋白水平的表达及意义。[方法)用免疫组化染色(LSAB法)分别检测30例肝癌组织和癌旁肝组织中TGF-β1RⅡ的表达。[结果]TGF-β1RⅡ染色,在肝癌组织以阴性(14例)和弱阳性(10例)为主;在癌分组织以弱阳性(8例)和阳性(11例)为主。经统计学处理,两组差别有显著性意义(P<0.05)。(结论]TGF-β1RⅡ在肝癌组织表达降低,导致肝癌细胞及性生长调控障碍,可能是其癌变和生长失控的重要原因之一。
[Purpose]To investigate the protein expression of Transforming Growth Factor-β1 RⅡ receptor (TGR-β1R Ⅱ)in hepatocellularcarcinoma(HCC). [Methtod]The protein expression of TGF-β1 RⅡ mRNA in 30 cases of HCC hssue and its surrounding tissue was detectedseparately by immunchistochemical technique(LSAB). [Result] The stairing of TGF-β1 RⅡ protein was mainly negative (14 cases )and weaklypositive(10 cases) in HCC tissue; while in the surrounding liver tissue,the staining was mainly positive(11 cases)and weakly positive(8 cases) .Therewas sigmhcant difference between two groups(P<0.05). [Conclusion]The decrease expression of TGF-β1 RⅡdecrease expression of TGF-β1 RⅡ by tumorous hepatocyte leads to thedefect of its negative growth regulation,and this may be one of the most important reasons for its carcinogenes and uncontrolled growth.
关键词
肝细胞肝癌
TGF-β1RⅡ
免疫组化
Hepatocellular carcinoma Transforming Growth Factor-β_1 type Ⅱ receptor