放射联合活血化瘀中药治疗鼻咽癌疗效观察

Effect of Combination of Traditional Chinese Medicine and Radiotherapy on Nasopharyngeal Carcinoma

（目的）观察活血化瘀中药配合放射疗法治疗鼻咽癌的疗效。（方法）自1995年6月至1997年12月将初治鼻咽癌患者135例先行血液流变学检测共11项，其中3项以上异常者随机分为两组：常规放疗组（对照组）46例，放疗加中药组（试验组）60例。两组放疗方法及剂量相同。试验组在放疗同时口服中药活化生津液6ml/日。疗前、疗后观察口腔粘膜反应，肿瘤消退情况，血液流变学变化及免疫功能改变，近期生存率。（结果）试验组治疗后血液流变学有5项指标明显改善（P＜0．05）。试验组远处转移率3．31，对照组15．21（P＜0.05）。试验组和对照组1年生存率分别98.3％及97．8%,2年生存率分别为95.4％及94．34％（P值均＞0．05）。[结论]活血化瘀中药配合放射治疗鼻咽癌可以改善其血液高粘状态，改善微循环，减少远处转移。能否提高长期生存率尚待临床长期观察。

(purpose)To observe effect of Traditional Chinese medicine and combined with radiotherapy on nasopharyngeal carcinoma.(Method)From June 1995 to December 1997 eleven indexes of hemorrheology were tested in 135 cases of nasopharyngeal carcinoma before treatment.The patients with abnormal hemorrheology over 3 3 indexes were divided into two at random 46 patients received conventional radiotherapy (thecntrol group)and 60 patients received combination of combination of conventional radiotherapy with Traditional Chinese medicine (the trial group)Teh methods anddoses of radiotherapy were the same in the two groups ,ony in the trial group 60 ml Chinese medicines were taken orally per day .Side effects onmucous membrane of oral cavity, the size of tumor ,hemorrheology ,the function of immunity and the survival rates were observed befor and afterradiotherapy.(Results )Five indexes of hemorrheology were signficantly improved in the trial group affer radiotherapy(P,0.05). Metastatic ratewas 3.3% in the trial group and 15.2% in the controlgroup (P <0.05) .The 1 -,2- year survival rates in the trial group were 98.3%,95.4%respectively and the control group 97.8% '94.3 3% (P > 0. 05). [conclusions)Traditional Chinese medicine combined with radiotherapy may notonly improve high blood viscosity and microcirculation but also reduce the metastatic rate .Whaher it may mprove long survivalrate remain to befurther observed .