世界卫生组织老年认知功能评价成套神经心理测验的临床初步应用

The preliminary clinical use of the World Health Organization battery of cognitive assessment instruments for elderly

目的 验证世界卫生组织老年认知功能评价成套神经心理测验（ＷＨＯＢＣＡＩ） ，并探讨阿尔茨海默病（ＡＤ） 早期认知功能改变的特点。方法 采用ＷＨＯＢＣＡＩ对２６ 例轻中度ＡＤ 患者（ＡＤ组）、２７ 例轻度认知功能损害的老年人（ＭＣＩ组） 和８３ 名认知功能正常的老年人（ＮＣ组） 进行测试。结果 在全部（２５ 项） 测验中３ 组间比较差异均有非常显著性（ Ｐ＜ ０－０１）；两两比较，ＡＤ组与ＭＣＩ组［ 除１ 项（ 视觉再认） 外］和ＮＣ 组间的差异均有显著性（ Ｐ＜ ０－０５） ；ＭＣＩ组的词汇学习、词汇流畅性、小标记、视觉推理、连线、分类和空间结构测验差于ＮＣ组（Ｐ＜ ０－０５） 。结论 ＷＨＯＢＣＡＩ能很好地鉴别ＡＤ与ＭＣＩ和ＮＣ。

Objective To examine early cognitive change of Alzheimer disease using a battery of neuropsychological tests Methods 26 patients with mild and moderate Alzheimer′s disease (AD), 27 subjects with mild cognitive impairment (MCI) and 83 normal controls (NC) were assessed with the World Health Organization battery of cognitive assessment instruments for elderly (WHO BCAI) Results There were significant differences among the three groups in all 25 items of WHO BCAI tests Significant differences were observed in almost all the sub tests between AD group and NC group or AD group and MCI group Significant differences were found in verbal learning, verbal fluency, mini token, visual reasoning, trail making, sorting and spatial construction between MCI and NC Conclusions The WHO BCAI appropriately define AD, MCI and NC in their cognitive function, and some tests of it may be more sensitive in the early detection of Alzheimer disease