奥曲肽对犬急性重症胰腺炎Oddi括约肌的影响

The effect of sandostatin on sphincter of Oddi in acute severe pancreatitis in dogs

目的 观察急性重症胰腺炎时Ｏｄｄｉ 括约肌（ＳＯ） 的压力变化及奥曲肽对之影响。方法１５ 只犬分为２ 组，急性重症胰腺炎非治疗组（５ 只） ，奥曲肽组（１０ 只）；制备犬急性重症胰腺炎模型，于制备前、后及给药后各时间点分别测定ＳＯ的基础压和时相收缩幅度。结果 急性重症胰腺炎时ＳＯ压力显著升高（ Ｐ＝ ０．０００ １） ；奥曲肽能显著降低重症胰腺炎时ＳＯ的基础压（ Ｐ＝ ０．０００ ３） ，但对时相收缩幅度无影响（ Ｐ＝ ０．２３０ ５）。结论 急性重症胰腺炎时ＳＯ的压力变化将促进疾病的发展并影响其严重程度；而奥曲肽则通过对ＳＯ的抑制对重症胰腺炎起着有益的治疗作用。

Objective To study the pressure change of sphincter of Oddi (SO) in acute severe pancreatitis (ASP) and the effect of sandostatin on it. Methods Fifteen dogs were used and allocated into 2 groups: ASP untreated group and sandostatin group. The ASP model was prepared by retrograde ductal injection of a mixture of 5% taurocholic acid and autologous bile. SO manometic parameters including basal pressure (BP) and phasic contraction amplitude (PCA) were measured at each time spot before and after the preparation of ASP and after the administration of sandostatin. Results BP was obviously increased after ASP preparation and sandostatin could significantly decrease the BP of SO in ASP group but not PCA. Conclusion Dysmotility of SO might play an important role in the severity and progression of ASP. Sandostatin may have benificial effects in the treatment of ASP by decreasing BP of SO.