头部伽玛刀在低级别胶质瘤术后治疗中的应用

The clinical report of stereotactic radiosurgery for post-operational low-grade glial tumors

目的探讨头部伽玛刀在低级别胶质瘤术后治疗中的疗效和作用。方法回顾性分析自2008年3月至2009年12月38例伽玛刀治疗的低级别胶质瘤术后病人临床资料。肿瘤容积8.78±3.24cm3;边缘剂量14.56±3.98Gy,用40%～55%等剂量曲线覆盖病灶。结果平均随访时间10.2个月(1～24个月),头颅MRI检查显示治疗后3个月内79.31%(29/38)肿瘤缩小大于25%,3～6个月为88.2%(30/34),6～12个月为80%(20/25),12～24个月为70%(7/10)。治疗后12个月,仍有40%(4/10)肿瘤消失,2例出现症状性脑水肿。结论伽玛刀治疗是低级别胶质瘤手术治疗后一种有效、安全的方法。

Objective To investigate therapeutic effects of Gamma knife in post-operational low-grade glial tumors.Methods The data of 38 cases with low-grade astryoma after operation were retrospectively evaluated from March 2008 to December 2009.The patients were treated with Gamma Knife with peripheral prescription dose of 14.56±3.98 Gy to the volume of the solid parts 8.78±3.24 cm3 at 40%～55% isodose curve.Results 38 cases had been followed up from 1 to 24 months（averaged 10.2 months）.MRI examination showed that the tumor volume reduced more than 25% in 79.31%（29/38） cases within 3 months after treatments,and in 88.2%（30/34） cases at 3～6 months and in 80%（20/25） cases at 6～12 months and in 70%（7/10） cases at 12～24 months.The tumor disappeared in 40%（4/10） cases at 12 months after stereotactic radiosurgery.The symptomatic brain edema was found in 2 cases at 3 months after treatment.Conclusion Gamma knife radiosurgery is an effective and safe method to low-grade glial tumors after operation.