基质金属蛋白酶在寄生虫致脑部感染中的免疫病理作用

The Immunopathology Mechanisms of Matrix Metalloproteinases in Brain Infection Induced by Parasites

基质金属蛋白酶(matrix metalloproteinase,MMP)是内源性多肽酶类,参与机体的许多正常生理机能,如胚胎发育、创伤愈合、新生血管形成和软骨吸收等。但在感染过程中,过度表达活化的MMP常可导致免疫病理现象,引发疾病或死亡,而有利于病原体的播散或生存。疟原虫、刚地弓形虫、链状带绦虫囊尾蚴和广州管圆线虫幼虫等人体寄生虫可侵入宿主中枢神经系统,引发嗜酸粒细胞浸润为主的炎性反应。本文综述了有关寄生虫导致脑部感染时MMP的作用及其病理机制。

Matrix metalloproteinase （MMP）family is a class of endogenous peptidases involved in normal physiological processes of the body,such as embryonic development,wound healing,angiogenesis,cartilage absorption. etc.However,during infection,over-expression of activated matrix metalloproteinase can lead to immunopathological change,induce disease or death,also contribute to the spread or survival of pathogens.Some human parasites such as Plasmodium,Toxoplasma gondii,Cysticercus cellulosae,A ngiostrongylus cantonensis larvae can invade the central nervous system,and cause inflammatory response dominated by eosinophil infiltration.This article reviews function and pathological mechanism of MMP during the infection of relevant parasites involving brain.