吸烟对阿尔茨海默病发病风险的meta分析

Meta-Analysis of the association between smoking and the risk for Alzheimer's disease

目的探讨吸烟对阿尔茨海默病(Alzheimer's disease)发病的影响。方法通过中国期刊网、High-Wire Press、Medline等数据库搜集资料,然后应用RevMan5.0软件对所得资料进行META分析,选用随机效应模型进行合并效应量。结果经过文章质量的评价,共筛选出病例对照研究24篇,纳入病例人数3187,对照人数4607。对所选文献的资料进行异质性检验后认为资料存在中度的异质性(2=39.71P=0.03;I2=37%),最后对资料进行合并得出合并值(OR=0.75,95%CI:0.65～0.86),但2001年份以后研究结果的模型却不具有统计学意义(OR=0.85,95%CI:0.72～1.01,Z=1.79,P=0.07)。结论吸烟对阿尔茨海默病发生的影响有待进一步研究。

Objective To study the impact of smoking on Alzheimer＇s disease.Methods The references were retrieved through the databases of CNKI,HighWire Press ,Medline.The fixed effects model of the meta-Analysis was then chosen to analysis the data from references by Revman version 5.0.Results There were twenty-four references including 3187 cases and 4607 controlled left after quality evaluation.The homogeneity of the references was moderate after test of heterogeneity（x2=39.71,P=0.03,I2=37%）.The pooled odds ratio was 0.75 and the confidence interval was 0.65~0.86.However ,the analysis of data obtained after 2001 did not show an positive correlation（OR=0.85 ,95%CI：0.72~1.01,Z=1.79,P=0.07）.Conclusions The further study is needed to study the association between smoking and AD.