摘要
为了探讨甲亢、甲减患者细胞损伤程度的变化,本文应用放射免疫方法(RIA)对甲亢、甲减患者与正常人血清进行了甲状腺功能的测定,同时用改良TBA微量法测定三组血清丙二醛(MDA)含量的变化,进一步进行其相关性分析。结果显示;甲亢组MDA水平显著高于正常对照组(P<0.01),甲减组MDA水平与正常对照组无显著性差异(P>0.05),甲亢组血清MDA水平显著高于甲减组(P<0.01);但是MDA含量与T3、T4水平无相关性(r=0.085,P>0.05;r=0.076,P>0.05)。提示甲亢患者MDA水平的变化,可能是由于细胞代谢增强导致的细胞损伤引起。
In order to discuss the damaged dregree of cells with hyperthyroidism and hypothyroidism patients,The faction of thyroid was determined in hyperthyroidism and hypothyroidism patients by RIA,sametimes,the MDA content in serum was also determined by a method of modificatory TBA microdetermination,a correlative analysis was done among them.The results showed that MDA content in serum of hyperthyroid group was significantly increased than that of hypothyroid and control group (P <0.01),but there were no line correlation between MDA and T3,T4.It suggested that the change of a MDA level in serum of hyperthyroidism patients may be due to cell damage by cell metabolism increased.
关键词
甲亢
甲减
丙二醛
血清
测定
Hyperthyroidistn Hypothyroidism MDA
