多西紫杉醇经动脉或静脉灌注对后肢VX2瘤兔的影响

Effects of intra-arterial infusion therapy or systemic chemotherapy with docetaxel for VX2 tumor in rabbit hind limb

目的探讨多西紫杉醇经动脉灌注治疗肿瘤的有效性及安全性。方法建立兔后肢VX2瘤动物模型。经股动脉或耳像静脉灌注多西紫杉醇。比较两种给药方式下实验兔的肿瘤组织、胃壁、肝脏、肾脏、血浆的药物浓度差异。采用t检验作统计学分析。结果经动脉灌注组的肿瘤组织、胃壁、肝脏及肾脏的药物浓度均高于经静脉灌注组。肿瘤组织及胃壁中的药物浓度差异有统计学意义(P<0.05)。肿瘤组织的药物浓度差别约为14倍,经动脉灌注组的血浆药物浓度低于经静脉灌注组,两者差异没有统计学意义(P>0.05)。结论多西紫杉醇经动脉灌注可提高肿瘤的局部控制效果,但有可能增加毒副反应发生的风险,应慎重采用或减少用药剂量。

Objective To discuss the efficacy and safety of intra-arlerial infusion therapy with docetaxel. Methods Animal model of VX2 tumor in rabbit hind limb was set up. lntra-arterial infusion therapy or systemic chemotherapy with doeetaxel was performed. Cnrmentrations of doeetaxel in VX2 tumor, wall of stomach, liver, kidney and plasma of rabbits with VX2 tmnors in hind limbs were deterulined. Difference of drag concentrations between intra-arterial infilsion therapy and systemic chemotherapy was compared using Student t-test. Results Concentrations of do- cetaxel in VX2 tumor amt wall of stomach of rabbits with intra-arterial infusion therapy were significantly higher than those with systemic chemotherapy （P〈0.05）. The drug concentration in VX2 tumor of rabbits with intra-arterial infusion was 14 times higher than that with svstemic chemotherapy. Concentration ofdocetaxel in plasma of rabbits with intra-arterial infusion therapy was not significantly lower than that with systemic chemotherapy （P〉0.05）. Conclusion lntra-arterial infusion therapy with docelaxel for tumor is effective. However, there is increased risk of toxicity and the dose should adjusted accordingly.