Interleukin-1β with learning and memory

白介素1β与学习和记忆(英文)

Interleukin-1β（IL-1β）is one of the first cytokines ever described.It has long been recognized to play an important role in mediating inflammation and orchestrating the physiological and behavioral adjustments that occur during sickness. Recently,accumulating evidence has indicated that IL-1β also adversely affects cognitive function.Nevertheless,there are also some reports showing no effects or even beneficial effects of IL-1β on learning and memory.The relationship between IL-1β and cognitive impairment has not been clearly elucidated.Here we reviewed the evidence of both negative and positive effects of IL-1β on learning and memory,and the key factors that may affect the effects of IL-1β on learning and memory were discussed.

白介素1β是最早被研究的细胞因子之一。白介素1β调节炎症以及在病态时协调生理和行为变化的重要作用早已被研究者认可。最近越来越多的研究表明白介素1β可能会损害认知功能,但也有一些研究报道白介素1β对学习记忆没有损伤甚至有促进作用。因此,白介素1β与认知损伤之间的关系尚不十分清楚。本文对白介素1β损害或促进学习记忆的实验数据进行了综述,并对可能影响白介素1β对学习记忆作用的一些关键因素进行了讨论。