沙美特罗/氟替卡松治疗COPD对患者肺功能和气道炎症的影响

Effect of Salmeterol/Fluticasone on Lung Function and Airway Inflammation in Patients with COPD

目的探讨沙美特罗/氟替卡松治疗慢性阻塞性肺疾病(COPD)对患者肺功能和气道炎症的影响。方法 回顾性分析2009年11月-2010年4月馆陶县人民医院收治的118例COPD患者的相关临床资料,采用沙美特罗/氟替卡松治疗的60例作为观察组,仅采用常规治疗的58例作为对照组,对两组患者肺功能和气道炎症改善情况进行比较分析。结果观察组治疗后6个月内患者的急性发作次数及住院时间均明显少于对照组,两组间差异有统计学意义(P<0.05);治疗后观察组患者的一秒率(FEV1.0%)、血清肿瘤坏死因子α(TNF-α)、转化生长因子β(TGF-β)均明显优于对照组,差异有统计学意义(P<0.05)。结论沙美特罗/氟替卡松治疗COPD疗效显著,能明显改善患者的肺功能和气道炎症情况,值得在临床推广应用。

Objective To investigate the effect of salmeterol/fluticasone on lung function and airway inflammation in patients with chronic obstructive pulmonary disease（COPD）. Methods The clinical data of 118 inpatients with COPD in our hospital from November,2009 to April,2010 were retrospectively analyzed.60 patients treated with salmeterol/fluticasone were served as the observation group,and 58 patients received routine treatment were served as the control group.The lung function and airway inflammation improvement of the two groups were compared and analyzed. Results Within 6 months after the treatment,the acute exacerbation frequency and the length of hospital stay in the observation group were significantly less than those in the control group,and the difference was statistically significant（P0.05）.After the treatment,the second rate（FEV1.0%）,serum levels of tumor necrosis factor α（TNF-α）,transforming growth factor β（TGF-β） of the observation group were significantly better than those of the control group,and the difference was statistically significant（P0.05）. Conclusions Salmeterol/fluticasone has a definite curative effect on COPD,and it can significantly improve lung function and airway inflammation of the patients.It is worthy of clinical application.