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β_2肾上腺素能受体基因46A/G多态性与原发性高血压并冠心病的关系 被引量：2

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摘要 目的探讨β2肾上腺素能受体(β2-AR)基因46A/G多态性与原发性高血压(PH)并冠心病(CHD)的关系。方法应用聚合酶链反应—限制性片段长度多态性方法,检测102例PH(PH组)、98例PH并CHD(PH+CHD组)患者及116例健康者(正常对照组)的β2-AR基因型。结果 PH组、PH+CHD组G等位基因频率分别为46.6%、46.4%,均高于正常对照组的36.6%(P<0.05);PH组与PH+CHD组比较无统计学差异(P>0.05)。结论β2-AR基因可能是中国汉族人PH的重要遗传因素,该基因与PH患者是否易患CHD无关。
作者 高建步 李玉东 杨守忠 毛绍芬 哈黛文
机构地区 南阳市中心医院 武汉大学中南医院
出处 《山东医药》 CAS 北大核心 2011年第5期41-42,共2页 Shandong Medical Journal
关键词 高血压 冠心病 Β2-肾上腺素能受体基因
分类号 R544.1 [医药卫生—心血管疾病]
  • 相关文献

参考文献8

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共引文献510

同被引文献28

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二级引证文献3

山东医药
2011年 第5期

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