白细胞计数与代谢综合征的相关性研究

Correlation of white blood cell count with metabolic syndrome

目的了解山西某电厂人群代谢综合征(MS)的患病率和MS与白细胞(WBC)计数的相关性。方法对1 030名某电厂职工进行健康体检,测定了血糖、血脂、血压、白细胞计数(WBC)等指标,其中按标准共纳入1 014人,参考美国国家胆固醇教育计划成人治疗组第3次指南(NCEP-ATPⅢ)标准诊断MS。结果 MS的患病率为18.3%,男性(20.7%)多于女性(16.5%)。WBC计数随着构成MS条件的增加逐渐升高(P<0.01),校正年龄及MS其他组分后,男性WBC计数与腰围、舒张压呈正相关(P<0.05),也与甘油三酯(TG)呈明显正相关(P<0.01);女性WBC计数与腰围、收缩压、舒张压和TG呈正相关(P<0.05)。男性白细胞四分位数分组Quartile4(≥7.6×109 cell/L)患有MS的风险性是Q1(<5.5×109 cell/L)的5.3倍。女性患MS的风险性随WBC的增加逐步升高(OR=1.0,1.1,1.7,2.5)。结论 WBC计数作为炎症标志物,与MS及参与构成MS条件有相关性,WBC计数增高可能是MS发生的标志物之一。

Objective To study the prevalence of metabolic syndrome（MS） in a power plant of Shanxi province and its correlation with the white blood cell（WBC）count.Methods Health examination was carried out in 1 030 employees of a power plant in Shanxi province.The blood glucose,blood lipid,blood pressure,WBC count were determined.Among 1 030 employees,1 014 were enrolled in this study.MS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel Ⅲ（NCEP-ATPⅢ） of American.Results The total prevalence rate of MS was 18.3%,20.7% for male and 16.5% for female.The WBC count gradually elevated along with the increasing components of MS（P0.01）.After the adjustment of age and other components of MS,the WBC count in male was positively related to the waist circumference（P0.05）,diastolic pressure（P0.05） and the triglyceride（TG） level（P0.01）,while in female,it was also positively related to waist circumference,systolic and diastolic pressure and TG（P0.05）.The risk of MS in the forth quartile of male WBC count（WBC≥7.6×10^9 cell/L） was 5.3 folds of the first quartile（WBC5.5×10^9 cell/L）.As for female,the risk gradually increased along with the elevation of WBC count（OR=1.0,1.1,1.7,2.5）.Conclusion The WBC count,as a classic inflammatory marker,is correlated with MS and its components.Elevated WBC count may indicate the occurrence of MS.