灼口综合征患者心理健康状况与血清IL-6、TNF-α水平的关系

Correlation of psychological profiles with serum levels of IL-6,TNF-α in patients with burning mouth syndrome

目的探讨灼口综合征(BMS)患者心理健康状况与血清IL-6、TNF-α水平的相关性。方法实验组选择灼口综合征(BMS)初诊患者22例,其中女性19例,男性3例。对照组为20例年龄、性别相似的健康人。在晨9:00平和状态下抽空腹静脉血2 ml,采用酶联免疫吸附实验(enzyme-linked immunosorbent assay,ELISA)双抗体夹心法检测血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,采用症状自评量表(SCL-90)评定两组人群的心理健康状况。结果实验组血清IL-6水平显著低于对照组(P<0.05),两组间TNF-α水平差异无统计学意义(P>0.05),SCL-90总分和9个因子得分实验组均明显高于对照组(P<0.05),绝经前妇女SCL-90总分和9个因子得分均高于绝经后妇女,其中躯体化、焦虑、敌对在两组间差异有统计学意义(P<0.05)。IL-6、TNF-α与精神因素无相关性。结论精神因素在BMS的发生发展中起着极其重要的作用,但灼口综合征患者心理健康状况与血清IL-6、TNF-α水平无相关性。

Objective To explore the correlation of psychological profiles with serum levels of IL-6,TNF-α in patients with burning mouth syndrome.Methods Twenty-two patients first diagnosed as BMS were enrolled（19 females and 3 males）.Twenty normal subjects were chosen as controls with similar age and sex.The fasting blood of 2 ml was drawn from the subjects under restine conditions in the morning to examine the serum levels of IL-6 and TNF-α by ELISA.SCL-90 was used to evaluate the psychological profiles.Results Compared with controls,the serum level of IL-6 significantly decreased in BMS patients（P0.05）,but the level of TNF-α had no significant change（P0.05）.The scores of SCL-90 were significantly higher in BMS patients than those in the controls（P0.05）.SCL-90 scores were higher in the premenopausal women than that in postmenopausal women,and there was significant difference in somatization,anxiety and hostile between them（P0.05）.The psychological profiles were not correlated to serum levels of IL-6 and TNF-α.Conclusion The psychogenic factors exert very important roles in the development of BMS,but psychological profiles are not correlated to serum levels of IL-6 and TNF-α.