二甲双胍对原发性高血压伴糖耐量异常患者左心室舒张功能的影响研究

Metformin on Patients with Essential Hypertension with Impaired Glucose Tolerance of Left Ventricular Diastolic Function

目的研究二甲双胍对原发性高血压伴糖耐量异常的患者左心室舒张功能的影响。方法选取60例原发性高血压伴糖耐量异常的患者。随机分为两组,A组30例在常规降血压治疗基础上服用二甲双胍治疗,B组30例仅给予常规降血压治疗。结果经治疗,A组患者较B组患者左心室舒张功能有所改善,差异有统计学意义(P<0.05)。结论二甲双胍对原发性高血压伴糖耐量异常的患者左心室舒张功能有一定的改善作用。

Objective To investigate the effects of metformin treatment on left ventricular diastolic function of essential hypertensive patients with impaired glucose tolerance.Methods 60 essential hypertension patients were divided randomly into 2 groups（group A and group B）,every group have 30 patients.Group A treated by metformin based on routine hypotensive therapy,group B only treated by routine hypotensive therapy.Results Left ventricular diastolic function of patients in group A was improved greater than group B,the improvement has statistical difference（P0.05）.Conclusion Left ventricular diastolic function of essential hypertension patients with impaired glucose tolerance could be improved by metformin treatment.