550份血培养阳性标本细菌分布及耐药性分析

Bacteria distribution and antimicrobial resistance analysis in 550 cases of positive blood cultures

目的了解血培养阳性标本细菌分布及耐药情况。方法回顾分析2007年7月至2010年7月浏阳市人民医院住院患者送检的血培养阳性标本,采用VITEK32全自动细菌分析仪进行鉴定及药敏试验。结果 550份血培养阳性标本中革兰阳性菌362株,占65.8%,以凝固酶阴性葡萄球菌、金黄色葡萄球菌为主,对第1代头孢耐药率较高;革兰阴性菌164株,占29.8%,以大肠埃希菌、铜绿假单胞菌、克雷伯菌属为主。结论血培养分离的病原菌以革兰阳性菌为主,病原菌种类较多,耐药率较高,提示应高度重视合理使用抗菌药物,减少细菌耐药性产生,以提高临床治疗效果。

Objective To understand the bacteria distribution status of positive blood cultures and their drug resistance.Methods The retrospective study on the positive blood cultures in inpatients from July 2007 to July 2010 was performed.The VITEK32 automatic analyzer was used for bacterial identification and susceptibility test.Results Among 550 cases of positive blood cultures,362 cases were Gram-positive bacteria,accounting for 65.8%,and dominated by coagulase negative staphylococcus and Staphylococcus aureus with high resistance to first generation cephalosporin;164 cases were Gram-negative bacteria,accounting for 29.8%,and dominated by Escherichia coli and Klebsiella.Conclusion Pathogens isolated from blood cultures are dominated by Gram-positive bacteria,with various types and high antimicrobial resistance rate,suggesting that more attention should be paid to rational use of antibiotics for reducing bacterial resistance to antibiotics and increasing the therapeutic effects in clinic.