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多囊卵巢综合征患者血清preptin与胰岛素抵抗相关性研究 被引量：6

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摘要 目的研究多囊卵巢综合征(PCOS)患者血清preptin水平变化以及preptin水平与胰岛素抵抗的关系,探讨其在PCOS病理生理过程中的作用。方法选择未合并糖尿病的PCOS患者41例作为研究对象,同期选择正常女性60例作为对照,测定血清preptin水平及内分泌代谢指标。结果 (1)PCOS组血清preptin水平高于对照组(P<0.05);PCOS非胰岛素抵抗组血清preptin水平低于PCOS胰岛素抵抗组(P<0.05),但仍高于正常对照组(P<0.05),差异有统计学意义。(2)preptin与甘油三酯(TG)(r=0.17,P<0.01)、高密度脂蛋白胆固醇(HDL-C)(r=0.19,P<0.01)、2h糖耐量(2hOGTT)(r=0.18,P<0.05)、胰岛素抵抗指数(HOMA-IR)(r=0.20,P<0.01)呈正相关,与体重指数(BMI)、腰臀比(WHR)、空腹血糖(FBG)、空腹胰岛素(FINS)无关。结论 preptin可能在PCOS患者胰岛素抵抗发生的病理生理过程中扮演了潜在的推动性角色,可能成为评价PCOS患者体内早期血糖代谢失衡的早期指标。
作者 奚杰 孙大伟 张敏 刘世凯 刘丹彤 黄平
机构地区 沧州市中心医院妇一科 吉林油田总医院微创妇科
出处 《中华临床医师杂志（电子版）》 CAS 2011年第3期176-178,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 多囊卵巢综合征 胰岛素分泌细胞 胰岛素抗药性 PREPTIN
分类号 R711.75 [医药卫生—妇产科学]
  • 相关文献

参考文献10

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二级参考文献16

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共引文献93

同被引文献42

  • 1吴茂林,闫和平.中医药同步调控精卵功能治疗不孕不育症的临床研究[J].中国性科学,2006,15(4):29-29. 被引量：9
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  • 4Yang G,Li L,Chen W et al.Circulating peptin levels in nor-mal,impaired glucose tolerance,and type 2 diabetic subjects(J).Ann Med,2009,41(1):52.
  • 5Antonio LM,Alfredo CA,Gaspare S et al.Metformin treatment of PCOS druing adolescence and the reproductive period(J).Eur J Obstet Gynecol Reprod Biol,2011,121(1):3.
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  • 7Rautio KT,Katrina MP,Laure CT et al.Rosiglitazone treat-ment alleviates inflammation and improves liver function in o-verweight women with polycystic ovary syndrome:a random-ized placebo-controlled study(J).Fertil Steril,2007,87(1):202.
  • 8Rotterdam ESHRE/ASRM-Sponsored PCOS ConsensusWor-kshop Group.Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syn-drome(J).Fertil Steril,2010,81(1):19.
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  • 10Ovalle F,Azziz R.Insulin resistance,polycystic ovary syn-drome,and type 2 diabetes mellitus(J).Fertil Steril,2010,77(6):1095.

引证文献6

二级引证文献29

中华临床医师杂志（电子版）
2011年 第3期

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