卵泡穿刺术治疗多囊卵巢综合征的临床研究

Clinical Research of Follicle Puncture in Treatment of Patients with Polycystic Ovary Syndrome

目的探讨超声引导下经阴道穿刺未成熟卵泡对多囊卵巢综合征(PCOS)不孕患者的影响。方法选择34例PCOS患者,在B超引导下行经阴道卵巢穿刺术。观察手术前后内分泌激素水平和两侧卵巢窦卵泡数。结果术后睾酮(A)、雄烯二酮(T)、两侧卵巢的窦卵泡数明显低于术前(8.73±2.84)vs(6.17±0.74),(3.38±0.52)vs(2.03±0.25),(16.72±3.63)vs(7.23±3.45),与术前比较,差异有统计学意义(P<0.01)。血清黄体生成素(LH)较术前明显下降(15.67±4.27)vs(9.41±2.86),与术前比较,差异有统计学意义(P<0.05),治疗后取得较高的排卵率(82.35%)和妊娠率(55.88%)。结论超声引导下卵泡穿刺术能改善PCOS不孕患者内分泌状况,减少卵巢基础窦卵泡计数,提高周期妊娠率。

Objective To evaluate the efficacy of ultrasound-guided immature follicle puncture technique （IMFP） in patients with polycystic ovary syndrome（PCOS）. Methods Thirty-four patients with PCOS were treated with transvaginal ultrasound-guided follicle puncture. Serum levels of LH, FSH, A, T and the basic follicle number were monitored before and after the treatment. Results The serum levels of A, T and the basic follicle number were decreased significantly after treatment （8.73±2.84）vs（6.17±0.74）,（3.38±0.52）vs（2.03±0.25）,（16.72±3.63）vs（7.23±3.45）,there were statistical difference（P 0.01）, the levels of LH was decreased significantly after the operation（15.67±4.27）vs（9.41±2.86）,there were statistical differences（P 0.05）, ovulation rate（82.35%） and pregnancy rate（55.88%） were increased. Conclusion IMFP treatment can improve the abnormal endocrinology, decrease the basic follicle number of the ovary, and achieve pregnancy in following cycles in PCOS patients.