冠心病患者血尿酸、高敏C反应蛋白检测的临床意义

Clinical significance of measurement of serum uric acid and high sensitivity C-reactive protein in patients with coronary heart disease

目的：观察冠心病患者血清尿酸（UA）、高敏C反应蛋白（hs-CRP）含量的变化及临床意义。方法：96例冠心病患者根据冠脉造影结果分为单支病变组（30例）、双支病变组（50例）和三支病变组（16例）,测定其UA、hs-CRP水平,并且与42例冠脉造影正常的胸痛患者（正常对照组）比较。结果：与正常对照组的UA含量（329.81±42.25）mmol/L,hs-CRP含量（2.69±0.81）mg/L相比,冠心病组的UA、hs-CRP含量均明显增加（P均〈0.001）,且随着病变支数的增加（单支,双支,三支病变）,UA、hs-CRP含量明显增加[UA（359.97±32.09）mmol/L：（383.32±39.31）mmol/L∶（420.81±36.47）mmol/L,hs-CRP（4.06±1.02）mg/L∶（6.36±0.78）mg/L∶（8.10±0.64）mg/L,P〈0.05~〈0.01],UA、hs-CRP水平与病变积分呈正相关（r=0.857,P〈0.001;r=0.915,P〈0.05）。结论：尿酸、高敏C反应蛋白含量与冠心病病变程度成正相关,是冠心病的危险因素。

Objective：To observe changes and clinical significance of levels of serum uric acid（UA） and high sensitivity C-reactive protein（hs-CRP） in patients with coronary heart disease（CHD）.Methods：According to result of coronary angiography,96 CHD patients were divided into single-vessel coronary disease group（n=30）,double-vessel coronary disease group（n=50） and triple-vessel coronary disease group（n=16）.Levels of UA and hs-CRP of patients were measured and compared with those of 42 persons with normal coronary angiography（normal control group）.Results：Compared with normal control group,UA level（329.81±42.25） mmol/L,hs-CRP level（2.69±0.81） mg/L significantly increased in CHD group（P0.001 all）.As degree of coronary disease increased（single-vessel,double-vessel,triple-vessel coronary disease）,its levels of UA and hs-CRP increased,UA respectively was：（359.97±32.09） mmol/L vs.（383.32±39.31） mmol/L vs.（420.81±36.47） mmol/L,hs-CRP respectively was：（4.06±1.02） mg/L vs.（6.36±0.78） mg/L vs.（8.10±0.64） mg/L,P0.05~0.001.Levels of UA and hs-CRP were positively correlated with histopathologic scores（r=0.857,P0.001;r=0.915,P0.05）.Conclusion：Levels of uric acid and high sensitivity C-reactive protein are positively correlated with coronary heart disease and they are risk factors for coronary heart disease.