摘要
目的:观察坎地沙坦联合卡维地洛治疗原发性高血压左室肥厚的疗效。方法:82例高血压患者被随机分为两组:观察组41例,予以坎地沙坦+卡维地洛;常规治疗组41例,予以氨氯地平+卡维地洛,共治疗12个月,观察用药后血压、左室结构的变化。结果:与治疗前比较,用药后两组收缩压[常规治疗组(166±14.0)mmHg∶(123±14.8)mmHg,观察组(168±14.5)mmHg∶(127±13.7)mmHg]和舒张压[常规治疗组(103±12.3)mmHg∶(76±13.6)mmHg,观察组(104±13.6)mmHg∶(79±13.2)mmHg]均显著降低(P均<0.05);两组治疗前后血压无显著差异(P均>0.05)。与治疗前比较,观察组室间隔厚度[(1.29±0.3)mm∶(1.12±0.2)mm]及左室后壁厚度[(1.21±0.2)mm∶(0.88±0.09)mm]均明显变薄(P均<0.05);左室重量指数[(138±27.9)g/m2∶(106±19.0)g/m2]明显减少(P<0.05),常规治疗组各项指标无明显变化(P>0.05),观察组较常规治疗组左室后壁厚度、左室重量指数显著改善(P均<0.05)。结论:坎地沙坦联合卡维地洛治疗原发性高血压左室肥厚患者,可安全有效降压,并同时逆转左室肥厚,改善左室舒张功能。
Objective:To observe the therapeutic effects of candesartan combined with carvedilol on left ventricular hypertrophy of essential hypertension(EH).Methods:A total of 82 EH patients were randomly divided into two groups:observing group(n=41),treated with candesartan and carvedilol;routine treatment group(n=41),treated with amlodipine and carvedilol.Changes of blood pressure and structure of left ventricle were observed after drug treatment.Results:(1)After drug treatment,systolic blood pressure [SBP,(123±14.8) mmHg vs.(166±14.0) mmHg] and diastolic blood pressure [DBP,(76±13.6) mmHg vs.(103±12.3) mmHg] significantly decreased in routine treatment group compared with before treatment(P0.05 all).In observing group,SBP [(127±13.7) mmHg vs.(168±14.5) mmHg] and DBP [(79±13.2) mmHg vs.(104±13.6) mmHg] also significantly decreased compared with before treatment(P0.05 all).There were no significant difference between two group for SBP and DBP change(P0.05 all).In observing group,interventricular septal thickness [TVST(1.12±0.2)mm vs.(1.29±0.3)mm],left ventricular posterior wall thickness [LVPWT(0.88±0.09)mm vs.(1.21±0.2)mm] and left ventricular mass index [LVMI(106±19.0)g/m2 vs.(138±27.9) g/m2] significantly decreased(P0.05 all) compated with befare treatment,and LVPWT、LVMI were less than those of routine treatment group(P0.05 all),but those indicators had no significant change after treatment in routine treatment group(P0.05).Conclusion:For patients with essential hypertension and left ventricular hypertrophy,combined treatment with candesartan and carvedilol can lower their blood pressure safely and effectively,and reverse left ventricular hypertrophy.
出处
《心血管康复医学杂志》
CAS
2011年第1期67-70,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
高血压
肥大
左心室
坎地沙坦
卡维地洛
Hypertension
Hypertrophy
left ventricular
Candesartan
Carvedilol