双黄连粉针与头孢呋辛钠粉针配伍稳定性考察

Study on compatible stability of shuanghuanglian powder injection and cefuroxime sodium powder

目的:考察双黄连粉针和头孢呋辛钠粉针配伍稳定性。方法:采用氯化钠溶液作为溶媒,考察双黄连粉针与头孢呋辛钠粉针在室温下配伍后外观、pH值和微粒变化,并采用HPLC法考察配伍液中黄芩苷含量的变化。结果:双黄连粉针与头孢呋辛钠粉针配伍产生白色沉淀,含量下降,有白色沉淀产生,微粒数增多。结论:双黄连粉针不宜与头孢呋辛钠粉针配伍。

Objective：To study the compatible stability of shuanghuanglian powder injection and cefuroxime sodium powder.Methods：The samples of complexes with the Sodium chloride solution as a solvent were collected at room temperature to study the changes of appearanc,pH and to determine content by using HPLC method.Results：White precipitate produced and then content decreased after mixing Shuanghuanglian powder injection with cefuroxime sodium powder.Conclusion：Shuanghuanglian powder could not combine with cefuroxime sodium powder for injection.