东莨菪碱及其制剂含量测定方法的研究进展

Advances in research on the methods for content determination of scopolamine and its preparations

东莨菪碱作为一种托品烷类生物碱,在临床上可用作麻醉前给药、晕动症的治疗。目前市场上的剂型有片剂、注射剂、贴剂、胶囊剂等,针对不同剂型对其含量测定也有不同方法。本文阐述了几种东莨菪碱不同剂型的含量测定方法并加以比较,其中HPLC法分离效率高,专属性好,灵敏度高,是目前最为常用的一种方法。

As a kind of tropane alkaloids,scopolamine can be used as preanesthesia medicine and in the treatment of motion sickness.There are many formulations of scopolamine preparations such as tablet,injection,patch,capsule and so on in the market.There are many different methods for content determination of scopolamine in different formulations.In this article,several methods for content determination of scopolamine in different preparations were introduced and compared.The HPLC method has the advantages of higher separation efficiency,better specificity,higher sensitivity than other methods and is used most widely for content determination of scopolamine in different preparations.