含卤代苯酚1,2,3-三唑衍生物的合成及抑菌活性

Synthesis and antibacterial activity of halogen phenolContaining 1,2,3-triazole derivatives

根据生物活性叠加原理,将"邻羟基苯基"和"1,2,3-三唑"分子片断合理组合,设计合成了3个新型1-(4-取代苯基)-4-(4-取代苯基)-5-氨甲基卤代苯酚-1,2,3-三唑类衍生物.目标化合物的结构经1HNMRI、R表征确认.抑菌活性测试表明,质量浓度为0.01%时,对白色念珠菌的抑菌率高达90%以上,是极具开发潜力的抗菌化合物.

A series of novel 1-（4-substituted phenyl）-4-substituted phenyl-5-ylimino methyl phenol-1,2,3-triazole derivatives were designed and synthesized by combining o-hydroxyl phenyl and 1,2,3-triazole,according to the superposition principle of biological activities.The three compounds are all novel.The structures of final products were characterized by 1HNMR and IR.The result of antibacterial assay showed that the title compounds had over 90% inhibitory rate against Monilia albican at 0.01% mass concentration.This shows that the target compounds is a great potential class of anti-fungal,anti-bacterial compounds.