创伤性脑损伤多效神经保护药物治疗研究进展

Recent Progress in Pleiotropic Neuroprotective Drug Therapy of Traumatic Brain Injury

创伤性脑损伤具有一个极为复杂的病理过程,有多种病理机制参与,并且相互作用。创伤性脑损伤神经保护药物研究至今尚无突破性进展,其中一个重要原因是阻断创伤性脑损伤单一机制或靶点的神经保护剂疗效有限。因此,多效神经保护可能是创伤性脑损伤神经保护策略之一。文章复习了近年来神经保护药物治疗研究进展,试图阐明多效神经保护概念,并介绍了数种正在研发的类似有多效神经保护作用的药物。

Traumatic brain injury is an extremely complex process that has a variety of pathological mechanism involved. There has been no breakthrough progress in neuroprotection on traumatic brain injury. One important reason is blocking traumatic brain injury in a single mechanism of nerve protective effect or targets. Given the multifactorial nature of the secondary injury process, it is unlikely that targeting a single factor will result in a significant improvement in outcome. Conversely, simultaneously targeting several injury factors may be the most likely therapeutic approach to improve outcome. This paper reviewed the recent progress of nerveprotective drug therapy, and tried to explain the pleiotropic neuroprotective concept, and introduce several kinds of developing pleiotropic neuroprotective drugs.