基于平坦性的昼夜节律模型的双参数控制

Flatness-Based Control in Two Parameters of Circadian Rhythm Model

利用Goldbeter五维果蝇昼夜节律模型,基于模型的平坦性性质,研究了同时控制2个参数ks,vd以实现1∶1导引的理论问题。结果表明,这种控制策略比只控制一个参数更具有鲁棒性,所得结果为生物节律恢复和疾病治疗提供了新的思路。

This paper focuses on the research of the restoration problem of the circadian rhythms in a drosophila model based on the flatness-based control theory.Besides,we can get the region which is the 1∶1 entrainment zone where the whole system follows the 24 hour period of input by controlling two parameters.The results show that our control strategy is more robust than previous one by controlling one parameter.This research result can provide new ways for restoring the circadian rhythms and treating disease resulting from rhythm.