高强度聚焦超声联合化放疗治疗大肠癌肝转移

High intensity focused ultrasound combined with chemoradiotherapy for treatment of liver metastasis from colorectal carcinoma

目的评价高强度聚焦超声联合化放疗与单纯化放疗治疗大肠癌肝转移的近期临床疗效。方法大肠癌肝转移93例,48例采用HIFU联合化放疗(HIFU组),与45例单纯采用化放疗(对照组)对比,评价两组的近期临床疗效。结果 HIFU组总有效率56.3%(27/48),对照组总有效率35.6%(16/45),两组有效率差异有显著性(P<0.05)。结论 HIFU联合化放疗治疗大肠癌肝转移近期有效率明显优于单纯化放疗。

Objective To evaluate the short-term clinical efficacy of high intensity focused ultrasound combined with chemoradiotherapy and chemoradiotherapy alone in treatment of the liver metastasis from colorectal carcinoma.Methods Of the 93 cases with the liver metastasis from colorectal carcinoma,48 were treated with high intensity focused ultrasound combined with chemoradiotherapy（HIFU group）,and 45 treated with chemoradiotherapy alone（control group）.The change of imaging before and after treatment and the short-term clinical efficacy of the two groups were evaluated.Results The overall response rate of the HIFU group was 56.3%（27/48）,and that of the control group was 35.6%（16/45）,the overall response rates of the two groups had significant difference（P0.05）.Conclusion The short-term clinical efficacy of high intensity focused ultrasound combined with chemoradiotherapy in treatment of the liver metastasis from colorectal carcinoma was better than that of chemoradiotherapy alone.