超声诊断胎儿神经管畸形及其相关发病因素分析

ANALYSIS OF NEURAL TUBE DEFECT AND RELATIVE FACTORS THROUGH PRENATAL ULTRASONOGRAPHIC SCREENING

目的通过超声检查和流行病调查了解胎儿神经管畸形分类,分析其相关发病因素。方法回顾性分析2005-2009年超声筛查确诊为胎儿神经管畸形89例,进行问卷调查,材料汇总,对比分析。结果胎儿神经管畸形89例,其中脑积水合并脊柱裂37例,脊柱裂5例,脑膨出9例,露脑畸形和无脑儿28例,无脑儿合并脊柱裂10例。神经管畸形发病因素与孕妇受孕季节、生活饮食习惯及人口学特征等密切相关。结论改变不合理生活饮食习惯,孕期加强营养,按时服用叶酸增补剂可预防神经管畸形发生。

Objective To investigate peripartum women having babies with neural tube defects by ultrasound diagnoses and to explore its influence factors. Methods The questionnaire was conducted for 89 peripartum women having babies with neural tube defects by ultrasound diagnoses during 2005 to 2009 in our hospital, and its influence factors were analyzed. Results Of the investigated women who had babies with neural tube defects, hydrocephalus with spina bifida was 37 cases, spina bifida 5 cases, encephalocele 9 cases, uncover brain abnormalities and anencephalus 28 cases, and anencephalus with spina bifida 10 cases. Pregnancy season ,diet habit and different demographic characteristics were related with the neural tube defects. Conclusion It is necessary to give up unhealthy diet habit and pay attention to strengthen nutrition, supplement folic acid regularly in order to prevent neural tube defects.