胸腺肽对恶性梗阻性黄疸术后感染并发症的防治作用探讨

Prevention and cure effect of thymosin on postoperative infectious complications of malignant obstructive jaundice

目的探讨胸腺肽对恶性梗阻性黄疸病人术后感染并发症的防治作用。方法将2005年5月~2010年7月本院收治的132例恶性梗阻性黄疸的患者分为治疗组（63例）和对照组（69例）,治疗组在手术治疗的基础上加用胸腺肽α1治疗,疗程为7 d,观察2组患者血液淋巴细胞变化以及术后感染的发生率。结果治疗组发生感染并发症13例,发生率20.6%（13/63）,对照组发生感染并发症24例,发生率34.8%（24/69）。2组感染并发症发生率差异具有显著性差异（P〈0.05）。术后第3、5、7、14天血淋巴细胞计数对照组明显低于治疗组（P〈0.01）。结论 胸腺肽可有效降低恶性梗阻性黄疸术后感染并发症发生率及病死率。

Objective To study the prevention and cure effect of thymosin on postoperative infectious complications of malignant obstructive jaundice.Methods One hundred and thirty-two cases with malignant obstructive jaundice from May 2005 to Jul.2010 were divided into the treatment group（n=43 cases） and control group（n=68 cases）.Thymosin-α1 was used in the treatment group for 1 week on the basis of operation.The changes in lymphocyte count and the incidence of postoperative infection were observed.Results The incidence of postoperative infectious complications in treatment group,20.6%（13/63） was remarkably lower than that in control group（34.8%,24/69,P0.05）.The level of lymphocyte count in treatment group was remarkably lower than that in control group during the 3rd,5th,7th and 14th days（P0.01）.Conclusion Thymosin could effectively reduce the malignant obstructive jaundice complication rate of postoperative infection and mortality.