半胱氨酸蛋白酶抑制因子C基因多态性与缺血性脑血管病的关系被引量：1

Relationship between polymorphism of cystatin C gene and ischemic cerebrovascular disease

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摘要目的探讨半胱氨酸蛋白酶抑制因子C(Cystatin C)基因CST3 G73A多态性与缺血性脑血管病的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析技术检测187例缺血性脑血管病患者(病例组)和122例正常对照者(对照组)Cystatin C基因G73A位点的多态性分布。结果 Cystatin C基因G73A在河南汉族人群中分布存在多态性,病例组GG、GA和AA基因型频率分别为55.1%、34.2%和10.7%,对照组中分别为64.8%、27.0%和8.2%,两组差异无统计学意义(χ2=2.859,P>0.05);A等位基因频率在病例组中的分布(27.8%)高于对照组(21.7%),但差异无统计学意义(χ2=2.886,P>0.05)。结论中国河南汉族人群Cystatin C基因G73A位点多态性可能与ICVD发病无关。 Objective To investigate possible association between the G73A polymorphism of the cystatin C gene and ischemic cerebrovascular disease（ICVD）.Methods Gene polymorphisms of cystatin C G73A were studied by polymerase chain reaction—restrictive fragment length polymorphism（PCR-RFLP） in 187 patients with ICVD and 122 healthy controls.Results The G73A polymorphism of the cystatin C gene existed in Han population in Henan,genotype frequencies of GG,GA and AA were 55.1%,34.2% and 10.7% in patients with ICVD and 64.8%,27.0% and 8.2% in controls,no statistical difference was observed between the cases and the controls（χ2=2.859,P0.05）;A allele frequency was slightly higher in ICVD group（27.8%） than that in the controls（21.7%）,but far from being statistically significant（χ2=2.886,P0.05）.Conclusion There may be no association between the G73A polymorphism of the cystatin C gene and ICVD.

作者张爱玲滕军放赵莘瑜

机构地区郑州人民医院神经内科郑州大学第一附属医院神经内科

出处《临床荟萃》 CAS 2011年第5期369-371,375,共4页 Clinical Focus

关键词动脉硬化脑缺血基因半胱氨酸蛋白酶抑制因子C arteriosclerosis brain ischemia gene cystatin C

分类号 R743.3 [医药卫生—神经病学与精神病学]

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