摘要
目的观察缬沙坦对原发性高血压合并糖耐量异常患者血浆一氧化氮(NO)以及氧化应激的影响。方法 42例原发性高血压合并糖耐量异常患者口服缬沙坦80 mg,每日1次。选择40例正常人作为对照组。检测治疗前后血糖、餐后2小时血糖(2 hPG)、胰岛素抵抗指数(HOMA-IR)、采用硝酸还原法测定血清NO,采用生化法测定血浆中超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶(GSH-PX)和丙二醛(MDA)的含量。结果 42例患者均完成试验,口服缬沙坦治疗8周末与对照组比较,患者组治疗前后比较2 hPG、HOMA-IR和血压明显下降,2 hPG治疗前(9.10±1.10)mmol/L vs治疗后(7.85±1.15)mmol/L(P<0.01);HOMA-IR治疗前3.90±2.11 vs治疗后2.73±1.71(P<0.01)。治疗前血压(160.71±13.10/99.10±11.78)mmHg(1 mmHg=0.133 kPa)vs治疗后(132.93±10.7/82.14±9.5)mmHg(P<0.01);与治疗前比较,治疗后血浆MDA显著下降,治疗前MDA(22.98±1.93)μmol/L vs治疗后(19.70±1.09)μmol/L(P<0.01)、与治疗前比较,患者组治疗后血浆GSH-PX、SOD和NO显著上升,GSH-PX治疗前(0.16±0.04)μmol/L vs治疗后(0.18±0.03)μmol/L(P<0.05);治疗前SOD(55.06±7.23)mU/L vs治疗后(63.07±6.78)mU/L(P<0.01);治疗前NO(38.10±7.36)μmol/L vs治疗后(43.38±7.52)μmol/L(P<0.01)。结论缬沙坦可改善高血压合并糖耐量异常患者血管内皮功能,减少氧化应激。
Objective To study the effects of valsartan on NO and peroxidation in essential hypertension(EH) with impaired glucose tolerance(IGT).Methods Forty-two patients of EH with IGT received valsartan(80 mg/d) orally once a day for eight weeks.Forty health adults served as controls.The levels of fasting blood glucose,postprandial 2 hour blood glucose,homeostasis model assessment index(HOMA-IR),serum nitric oxide(NO),glutathione peroxidase(GSH-PX),superoxide dismutase(SOD) and malonyldialdehyde(MDA) before and after treatment were measured.Results All 42 patients finished the therapy course.After oral treatment of valsartan for eight weeks,2 hPG,HOMA-IR,blood pressure and MDA in the patients group showed significantly more decrease compared with those of controls.The indexes in the patients group showed significant decrease between pre-and post-treatment,2 hPG(9.10±1.10) mmol/L vs(7.85±1.15) mmol/L(P0.01),HOMA-IR 3.90±2.11 vs 2.73±1.71(P0.01),blood pressure(160.71±13.10)/(99.10±11.78) mmHg vs(132.93±10.70)/(82.1±9.50) mmHg(P0.01),MDA(22.98±1.93) μmol/L vs(19.70±1.09) μmol/L(P0.01).In the patients group,the plasma GSH-PX,SOD and NO showed significant increase between pre-and post-treatment,GSH-PX(0.16±0.04) μmol/L vs(0.18±0.03) μmol/L(P0.05),SOD(55.06±7.23) mU/L vs(63.07±6.78) mU/L(P0.01),NO(38.10±7.36) μmol/L vs(43.38±7.52) μmol/L(P0.01).Conclusion Valsartan treatment improves endothelial function and decreases the oxidative stress in patients with EH.
出处
《临床荟萃》
CAS
2011年第6期482-483,487,共3页
Clinical Focus
关键词
高血压
糖尿病前期
缬沙坦
氧化性应激
hypertension
prediabetic state
valsartan
oxidative stress