新辅助化疗联合手术治疗直肠癌患者生活质量的研究

Investigation on Life Quality of Rectal Carcinoma Patients Following Neoadjuvant Chemotherapy Combined with Surgical Treatment

为研究新辅助化疗联合手术治疗对直肠癌患者生活质量的影响，回顾分析采用新辅助化疗联合手术治疗（治疗组）的直肠癌患者的资料，并与接受非新辅助化疗联合手术治疗（对照组）的患者生活质量、保肛率、术后并发症、3年生存率及不良反应进行对比分析。结果显示，治疗后两组患者功能子量表积分均较治疗前增高，差异均有统计学意义（P〈0．05）；症状子量表中疲倦、恶心欲呕吐、疼痛、食欲丧失、便秘、腹泻积分较治疗前降低，差异均有统计学意义（P〈0．05）。其中治疗组躯体功能、角色功能、情绪功能、社会功能积分增高更为明显，与对照组比较，差异有统计学意义（P〈0．05）。治疗组保肛率明显高于对照组，差异有统计学意义（P〈0．05）；两组术后并发症、3年生存率及化疗后不良反应发生率比较，差异无统计学意义（P〉0．05）。结果表明，新辅助化疗联合手术治疗可以提高直肠癌患者生活质量。

The objective of the study was to assess the influence of the neoadjuvant chemotherapy combined with surgical treatment （NC-ST） on the life quality of rectal carcinoma patients（RCP）. The clinical data of RCP who had undergone NC-ST were analized retrospectively （the treatment group）, and the outcomes were compared with that of patients who had not undergone NC-ST（but undergone surgical treatment and postoperative chemotherapy, ST-PC, the control group） in the status of the life quality, the ano-saving rate, postoperative complications, 3-year survival rate and adverse reaction. As results,in both groups, the scores in functional scales got higher than that before therapy（ P 〈0.05）;while the scores in the symptom scales （including fatigue,nausea and feel like vomiting, pain, anorexia, constipation and diarrhea） got lower after NC-ST and ST-PC（ P〈0.05）. The scores of somatization function,role function,mood function and social function were higher than that in the control group（ P 〈0.05）. The ano-saving rate in the treatment group was also higher than that in the control group（ P 〈0.05）. There was no statistical difference in postoperative complications,3-year survival rate and adverse reaction after chemotherapy between the two groups（ P 〉0.05）. It is concluded that NC-ST can enhance the life quality of patients with rectal carcinoma.