α1受体阻滞剂（特拉唑嗪）在输尿管下段结石促排石的疗效观察

Clinical efficacy of terazosin in the treatment of lower ureteral stones

目的 评价α1受体阻滞剂（特拉唑嗪）治疗输尿管下段结石的疗效.方法 90例诊断为输尿管下段结石患者随机分为2组（每组45例）.组1为对照组,给予双氯芬酸钠缓释片75mg/d,每天1次.组2为特拉唑嗪治疗组,在组1基础上加用特拉唑嗪2mg/d.结果 组1有18例排出结石,排石率40%,组2有39例排出结石,排石率86.66%,组1、组2比较,差异有统计学意义（P〈0.05）.组1结石平均排出时间11.16d,组2结石平均排出时间4.3d,组1、组2比较差异有统计学意义（P〈0.05）.4周内因再发绞痛而需要度冷丁镇痛治疗患者,组1有4例,组2有1例,组1、组2比较差异有统计学意义（P〈0.05）.结论 特拉唑嗪有促排石作用,能明显提高排石率,减少排石时间和镇痛药物需要.

Objective To evaluate the efficacy of terazosin （ an alphal - specific blocker） in the treatment of lower ureteral stones. Methods A total of 90 patients with lower ureter stones were randomly divided into 2 groups （45 in each group）. The patients in the group 1 （control group）were given sustained release tablets of diclofenac sodium 75 mg a day. Those in the group 2 were given terazosin 2 mga day besides the same treatment as the group 1. Results The stone - free rate was 86.66% in the group 2 （ 39/ 45 ） , significantly higher than that in the group 1 （40% , 18/45 ） （ P 〈 0.05 ）. The average stone removal recovery time in the groups 1 and 2 was 11.16 and 4.3 day respectively（ P 〈 0.05 ）. Ureteraleolie recurred within 4 weeks and analgesics were used in 4 cases in the group 1 and 1 case in the group 2 （ P 〈 0.05 ）. Conclusion alphal - blocker is safe and effective in the treatment of lower ureteral stones.