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基因工程小分子抗体及其在动物疾病研究中的应用 被引量：2

Applications of Genetic Engineered Recombinant Antibody Fragments in Animal Therapeutics and Diagnostics
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摘要 利用基因工程方法构建的小分子抗体,不仅具备亲本抗体可与抗原特异性结合的特征,更因其分子量小、组织穿透性强、免疫源性低、血液清除快、可经济方便地生产等优点在疾病的诊断和治疗中凸显出重要价值。文章对基因工程小分子抗体结构、抗体功能、在动物疾病研究中的应用等方面的进展情况进行了简要综述。 Genetic engineered recombinant antibody fragments are showing their increasingly prominent function in therapeutics and diagnostics because of their small molecular weight,strong penetrability in tissues,minimal immunogenicity,fast clearance rate in serum and low cost.In this review,the structure and function of genetic engineered recombinant antibody fragments are briefly presented.Furthermore,most current applications of these antibody fragments as animal therapeutics and diagnostics are included.
作者 赵蕾 林源 李本强 朱建国
机构地区 上海交通大学农业与生物学院上海市兽医生物重点实验室
出处 《中国兽药杂志》 2011年第2期41-46,共6页 Chinese Journal of Veterinary Drug
基金 外资合作项目"上海交大-美国Raybiotech联合开展抗体工程研究"
关键词 基因工程小分子抗体 抗体结构 抗体功能 应用 genetic engineered recombinant antibody fragments antibody structure antibody function application
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献44

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二级参考文献30

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共引文献5

同被引文献34

  • 1田占成,王云峰,童光志,刘光远.传染性支气管炎病毒疫苗研究进展[J].动物医学进展,2005,26(6):21-24. 被引量：14
  • 2吴庆儒,郭定宗,张桂荣,李文波.BSA对牛结核抗体ELISA检测的影响[J].动物医学进展,2007,28(5):5-9. 被引量：3
  • 3Schalm O W,Beach J R. Cultural requirements of the fowl coryza bacillus [ J ]. J Bacteriol, 1936, 31 ( 2 ) : 161-169.
  • 4Cavangh D, Naqi S A. Infectious brochitis[M]. In.. Sail A M,Fadly Y M,McDougald L R,et al. Diseases of Poultry (11th Eds. ), Ames: Iowa State University Press, Ames, IA, USA, PP, 2003: 101-119.
  • 5Cavanagh D. Coronavirus avian infectious bronchitis virus[J]. Vet Res, 2007,38 : 281-297.
  • 6Nina E Weisser, J Christopher Hall. Applications of single-chain variable fragment antibodies in therapeutics and diagnostics [J]. Biotechnology Advances, 2009,27(4) :502-520.
  • 7Christoph E Hagemeyer,Constantin von zur Muhlen, Dominik von Elverfeldt, et al. Single-chain antibodies as diagnostic tools and therapeutic agents[J]. Thromb Haemost, 2009,101(6) : 1012-1019.
  • 8Patrick Chames, Marc Van Regenmortel, Etienne Weiss, et al. Theraeutic antibodies: successes, limitations and hopes for the future[J]. British Journal of Pharmacology, 2009,157: 220-233.
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  • 10Huston J S, Levinson D, Mudgett-Hunter M, et al. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli[J]. Proe Natl Acad Sci USA, 1988,85(16) :5879-5883.

引证文献2

中国兽药杂志
2011年 第2期

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