手术与药物疗法治疗肝硬化伴脾功能亢进临床疗效比较

Clinical Effect of Operative Versus Drug Therapy for Liver Dysfunction of Patients with Liver Cirrhosis and Hypersplenism

目的比较手术与传统药物疗法治疗肝硬化伴脾功能亢进的临床疗效,寻找更有效的治疗肝硬化的方法。方法选择2008年1月～2010年1月入我院治疗的100例肝硬化伴脾功能亢进患者,分为手术组与药物组各50例。两组患者分别采用手术治疗与传统药物治疗,于治疗前、治疗后两周分别记录两组患者的治愈率,丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBil)、直接胆红素(DBil)、白蛋白(ALB)含量和主要不良反应发生情况,比较两种方法的治疗效果。结果两组患者治疗后与各自治疗前比较,各项指标的差异均有统计学意义(P<0.05)。另外手术组治疗后的各项指标要优于药物组,两组比较差异有统计学意义(P<0.05)。结论两种方法均对肝硬化患者有一定疗效,但手术治疗肝硬化伴脾功能亢进的疗效要优于传统药物治疗,建议肝硬化患者应早期手术,可提高疾病的治愈率。

Objective To observe clinical effect of drug therapy and operative therapies in liver dysfunction of patients with liver cirrhosis and hypersplenism. Methods 100 cases of liver cirhosis and hypersplenism were allocated into drug therapy group（n=50） and operative group （n=-50）. Clinical data including clinical manifestations,alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, total bilirubin（TBil） and direct bilirubin（Dbil）, ALB were analyzed in both groups before and after drug therapy or operative therapies. Clinical efficacy and safety of drug therapy and operative therapies in liver function of patients with liver cirrhosis and hypersplenism were evaluated by comparing the clinical data and adverse reactions in groups. Results Clinical data of two groups were significantly decreased at 2 weeks compared with 2 weeks ago. Clinical e^cacy and safety of operative therapies were better than drug therapy （P〈0.05）. Conclusion Both operative and drug therapies can significantly improve liver function of patients with liver cirhosis and hypersplenism,however,operative therapy has significantly advantage than drug therapy.