辛伐他汀治疗短暂性脑缺血发作患者颈动脉粥样硬化斑块的临床观察

Simvastation for Transient Ischemic Attack following Carotid Atherosclerosis

目的探讨辛伐他汀对短暂性脑缺血发作(TlA)患者颈动脉粥样硬化斑块的治疗作用。方法 96例有颈动脉粥样硬化斑块的TIA患者随机分为辛伐他汀组和对照组,各48例。辛伐他汀组除常规治疗外口服辛伐他汀,对照组口服血脂康。治疗前及治疗6个月后进行颈动脉超声检查,观察颈动脉内-中膜厚度(IMT)、动脉粥样硬化软斑块面积,并比较治疗6个月内两组患者脑血管事件的发生率。结果与治疗前相比,治疗后两组均有显著性差异(P<0.05)。两组治疗前比较差异无统计学意义(P>0.05),治疗后比较差异有统计学意义(P<0.05)。治疗6个月内辛伐他汀组缺血性脑血管病发生率低于对照组(P<0.05)。结论辛伐他汀增加剂量可有效地减少动脉粥样硬化斑块,降低缺血性脑血管病事件的发生。

Objective To evaluate the effects of simvastatin on patients with transient ischemic attack（TIA） following carotid atherosclerotic plaque.Methods 96 cases of TIA patients with carotid atherosclerosis plaque were randomly divided into simvastatin（statins） group and control group,48 cases in each group.The statins group took simvastatin except routine therapy for 6 months,while the control group took Xuezhikang.The ultrasonic examination of carotid artery intima-media thickness（IMT） and atherosclerosis area were carried out before and after treatment for both groups.The incident rates of cerebral vascular diseases within 6 months were compared between two groups.Results The ultrasonic examination showed significantly thinning of carotid IMT and reducing of plaque area in statins group（P0.05）,while there wasn＇t significant difference in control group（P0.05）.The cerebral vascular incident rates in statins group were lower than in control group（P0.05）.Conclusion Simvastatin may be more effective for antiatherosclerotic function with bigger dosage and decrease ischemic cerebral vascular incidence.