丙型肝炎病毒感染者血清HCV RNA拷贝数与甲胎蛋白含量的相关性分析

Correction Analysis of Serum HCV RNA Copies and Alpha-fetoproteinin Patients with Hepatitis C Virus Infection

目的分析丙型肝炎病毒（HCV）感染者血清HCVRNA拷贝数及甲胎蛋白（AFP）的含量，探讨HCVRNA拷贝数与AFP含量之间的相关性。方法收集临床已确诊的HCV感染者36例，其中男17例，女19例。通过实时荧光定量PCR法测定HCV感染者的HCVRNA拷贝数，采用化学发光免疫分析法测定血清AFP的含量。结果HCV感染者血清AFP含量均值为（5．7±5．1）ng／ml，明显高于正常人的AFP均值（3．5±2．3）ng／ml（P〈0．05），且HCV感染者的血清HCVRNA拷贝数与AFP含量呈正相关，相关系数为0．50（P〈0．01）。结论HCV感染者的血清AFP含量较正常人高，应定期随访和复查，以便早期发现肝细胞癌。

Objective To analyse the serum RNA copies of hepatitis C virug （HCV） and value of alpha-fetoprotein （AFP） in patients with hepatitis C virus infection,and to explore the correction of RNA copies bf hepatitis C virus to value of AFP. Methods Peripheral blood samples were obtained from 36 patients with hepatitis C virus infection （17 males and 19 female）. Copies of hepatitis C virus RNA were determined using real-time PCR technique. Serum levels of AFP were assayed by chemiluminescence method. Results The value of serum AFP in patients with hepatitis C virus infection was （5.7±5.1） ng/ml,which was higher than that of （3.5±2.3） ng/ml in the normal control group （P〈0. 05）. RNA copies of hepatitis C virus were significantly correlative to serum AFP in patients with hepatitis C virus infection,and the correla- tion coefficient was 0. 50 （P〈0. 01）. Conclusion The value of serum AFP in patients with hepatitis C virus infection was higher than that in the normal control group. The patients with hepatitis C virus infection should be observed and checked regularly in a time for early diagnose and treat cancer of liver.