摘要
目的分析丙型肝炎病毒(HCV)感染者血清HCVRNA拷贝数及甲胎蛋白(AFP)的含量,探讨HCVRNA拷贝数与AFP含量之间的相关性。方法收集临床已确诊的HCV感染者36例,其中男17例,女19例。通过实时荧光定量PCR法测定HCV感染者的HCVRNA拷贝数,采用化学发光免疫分析法测定血清AFP的含量。结果HCV感染者血清AFP含量均值为(5.7±5.1)ng/ml,明显高于正常人的AFP均值(3.5±2.3)ng/ml(P〈0.05),且HCV感染者的血清HCVRNA拷贝数与AFP含量呈正相关,相关系数为0.50(P〈0.01)。结论HCV感染者的血清AFP含量较正常人高,应定期随访和复查,以便早期发现肝细胞癌。
Objective To analyse the serum RNA copies of hepatitis C virug (HCV) and value of alpha-fetoprotein (AFP) in patients with hepatitis C virus infection,and to explore the correction of RNA copies bf hepatitis C virus to value of AFP. Methods Peripheral blood samples were obtained from 36 patients with hepatitis C virus infection (17 males and 19 female). Copies of hepatitis C virus RNA were determined using real-time PCR technique. Serum levels of AFP were assayed by chemiluminescence method. Results The value of serum AFP in patients with hepatitis C virus infection was (5.7±5.1) ng/ml,which was higher than that of (3.5±2.3) ng/ml in the normal control group (P〈0. 05). RNA copies of hepatitis C virus were significantly correlative to serum AFP in patients with hepatitis C virus infection,and the correla- tion coefficient was 0. 50 (P〈0. 01). Conclusion The value of serum AFP in patients with hepatitis C virus infection was higher than that in the normal control group. The patients with hepatitis C virus infection should be observed and checked regularly in a time for early diagnose and treat cancer of liver.
出处
《现代检验医学杂志》
CAS
2011年第1期128-129,共2页
Journal of Modern Laboratory Medicine