摘要
目的探讨乳腺癌组织中c-erbB-2和组织蛋白酶D(cath—D)的表达水平与临床病理及预后的关系。方法选取128例乳腺癌患者,采用免疫组化法检测c—erbB-2和cath—D蛋白的表达水平。并与患者的临床病理指标和预后做关联分析。结果c-erbB-2阳性率为36.5%,cath-D阳性表达率为40.9%。cath—D的表达水平与患者肿块直径大小显著相关,肿瘤直径〉5cm者cath—D的阳性率显著高于〈2cm者(x^2=21.0,P〈0.0001);cath-D阴性的68例中,24例(35.29%)有淋巴结转移,cath-D阳性者淋巴结转移率(63.83%)明显高于cath-D阴性者(P〈O.0001)。c—erbB-2表达比不表达患者预后差(P=0.01)。结论c-erbB-2阳性表达和cath-D阳性表达者,恶性程度高,易转移、预后差。
Objective To investigate the expression of c-erbB-2 and cathepsin D (cath-D) in primary breast carcinoma, and to analyze its relationship to the patients" clinicopathological status and its prognostic significance. Methods The immnohistochemical test were used to detect the expression of c-erbB-2 and cath-D in 128 patients with primary breast carcinoma. All data were statistically analyzed. Results The positive expression rate of c-erbB-2 and cath-D was 36.5 % and 40.9 %, relatively. Cath-D was correlated with tumor size (X^2=21.0, P 〈0.0001) and lymph node status (35.29 % vs 63.83 %, P 〈0.0001). The Kaplan-Meier curve and log rank test indicated that the positive c-erbB-2 expression was a significant prognostic factor for patients disease free survival (P〈0.01). Conclusion c-erbB-2 and cath-D show a clinicopathological invasive characteristic. They are prognostic factors for patients with primary breast carcinoma, and also can be prognostic indicator for patients.
出处
《肿瘤研究与临床》
CAS
2011年第2期103-105,共3页
Cancer Research and Clinic