肿瘤坏死因子α在妊娠不同时期及老化胎盘组织中的表达及意义

The expression of tumor necrosis factor-α and its significance in different gestational period placentas and aging placentas

目的探讨肿瘤坏死因子α（TNF—α）在妊娠不同时期胎盘组织中的表达变化及与胎盘老化的相关性。方法取早、中、晚各期和老化的胎盘组织，采用免疫组化的方法检测胎盘中TNF—α的表达和分布情况。结果TNF-α早孕组与晚孕组、老化组表达差异有统计学意义（P〈0．05）；中孕组与晚孕组、老化组表达差异亦有统计学意义（P〈0．05）；晚孕组与老化组的表达差异无统计学意义（P〉0．05）。结论TNF-α可能在胎盘老化过程中发挥重要作用。

Objective To study the differences of tumor necrosis factor-α in different gestational period placentas and aging placentas and to analyze its significances. Methods Using immunohistochemistry to detect the expression and distribution of tumor necrosis factor-α in different gestational period placentas and aging placentas. Results The expression of tumor necrosis factor-α was significantly higher in the third trimester of pregnancy placentas and aging group than in the first trimester of pregnancy placentas（ P 〈0.05 ） , and than in the second trimester of pregnancy placentas（ P 〈0.05）. The expression of tumor necrosis factor-α had no significant difference between the third trimester of pregnancy placentas and aging group（ P 〉 0.05 ）. Conclusion TNF-α should play an important role in placental aging.