诺和锐优化治疗对初诊2型糖尿病患者第一时相胰岛素分泌的影响

Effects of intensive instflin therapy by BIAsp on first-phase insulin secretion in newly diagnosed type 2 disbertics.

目的探讨诺和锐优化治疗对初诊2型糖尿病（他DM）患者第一时相胰岛素分泌缺陷的作用。方法对50例初诊T2DM患者进行每日3次诺和锐＋1次诺和平优化治疗2周，治疗前后分别行静脉葡萄糖耐量实验，测定0．3、4、5、8、10、120分钟血糖、胰岛素及c肽值，计算胰岛素和c肽曲线下面积（AUG）及稳态模型胰岛素抵抗指数（HOMA—IR）。结果患者治疗后血清胰岛素及c肽第一时相分泌明显增加．AUC0～10min均明显升高（P〈O．01）。HOMA—IR指数明显降低（P〈O．01）。结论优化治疗能明显改善初诊T2DM患者C肽的第一时相分泌及胰岛素敏感性。

Objective To explore the effects of transient therapy with BlAsp on first-phase insulin secretion in newly diagnosed type 2 diabetics. Methods Thirty newly diagnosed T2DM patients were treated with thrice daily BIAsp for 2 weeks. Intravenous glucose tolerance tests （IVGTT）were performed before and after the treatments. During IVGTT, levels of blood glucose, insulin and C-peptide at 1,3,4,5,8,10,120 minutes were measured. AUC of insulin and C-peptide were calculated. Results After treatment,AUC 0-120 min- utes were measured. AUC of insulin from 62.70 ±27.84 mlU× min/L to 96.46 ± 31.47mlU ± min/L（P 〈 0.01 ）and C-peptide from 5.23 ± 1.65nmol ± min/L to 7.21 ± 1.95nmol x min/L （P 〈 0.01.）Furthermore, HOMA-IR index was decreased （P 〈 0.01 ）. Conclusions Thrice daily BIAsp intensive insulin therapy significantly improves the first-phase insulin secretion in newly diagnosed T2DM patients.