期刊文献+

DC、CIK细胞协同治疗晚期恶性肿瘤的临床观察 被引量:5

下载PDF
导出
摘要 目的观察树突状细胞、细胞因子诱导的杀伤细胞协同治疗晚期恶性肿瘤的临床疗效。方法采集120例晚期恶性肿瘤患者外周血单个核细胞,贴壁细胞经IL-4、GM—CSF、TNF—d诱导,并经流式细胞仪检测证实为DC,悬浮细胞经CD3单抗、γ-干扰素、IL-2诱导,并经流式细胞仪检测证实为CIK细胞。DC、CIK细胞分次交替静脉输注。结果120例晚期恶性肿瘤患者中65例有可测量病灶,目前已观察到1例CR,15例PR,26例MR,20例SD,3例无变化,总缓解率为64.6%。结论DC—CIK细胞协同治疗晚期恶性肿瘤,疗效确切,毒副作用小,可以在临床上推广应用。
出处 《实用肿瘤学杂志》 CAS 2011年第1期6-9,共4页 Practical Oncology Journal
  • 相关文献

参考文献8

二级参考文献35

共引文献43

同被引文献64

  • 1Jing-Ting Jiang, Chang-Ping Wu, Lu-Jun Chen, Xiao Zheng, Department of Tumor Biological Treatment, Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China Yi-Bei Zhu, Jing Sun, Xue-Guang Zhang, Key Laboratory of Stem Cell of Jiangsu Province, Institute of Biotechnology, Key Laboratory of Clinical Immunology of Jiangsu Province, Soochow University, Suzhou 215123, Jiangsu Province, China Yue-Ping Shen, Wen-Xiang Wei, Department of Medicine, Soochow University, Suzhou 215123, Jiangsu Province, China Bin-Feng Lu, Department of Immunology, University of Pitts- burgh School of Medicine, Pittsburgh, PA 15261, United States.Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients[J].World Journal of Gastroenterology,2010,16(48):6155-6162. 被引量:82
  • 2秦福丽,张绍林,孙慧.CIK细胞的特点及临床应用[J].国外医学(肿瘤学分册),2004,31(11):824-826. 被引量:17
  • 3匡志鹏,梁安民.CIK细胞联合树突状细胞治疗恶性肿瘤的研究进展[J].现代肿瘤医学,2006,14(2):240-242. 被引量:22
  • 4袁玉涛,王志华,秦莉,张春艳,马玉彦,孙喜文.IL-24对细胞因子诱导的杀伤细胞的作用[J].世界华人消化杂志,2007,15(6):548-553. 被引量:9
  • 5Schmidt - Wolf IG, Negrin RS, Kiem HP, et al. Use of a SCID mouse/human lymphoma model to evaluate cytokine - induced killer cells with potent antitumor activity [ J ]. J Exp Med, 1991,174( 1 ) : 139 - 149.
  • 6Rakhmilevich AL, Timmins JG, Janssen K, et al. Gene gun -mediated IL - 12 gene therapy induces antitumor effects in the absence of toxicity : a direct comparison with systemic IL - 12 protein therapy [ J ]. J Immunother, 1999,22 ( 2 ) : 135 -144.
  • 7Inoue S, Hartman A, Branch CD, et al. MDA - 7 in combi- nation with bevaCizumab treatment produces a synergistic and complete inhibitory effect on lung tumor xenograft [J ]. Mol Ther, 2007,15 (2) : 287 - 294.
  • 8李成文.IL-2治疗的副作用[J].国外医学(输血及血液学分册),1997,20(3):169-172. 被引量:2
  • 9He J, Gu D, Wu X, et al. Major causes of death among men andwomen in China[J]. N Engl J Med, 2005, 353(11): 1124-1134.
  • 10Hsu HS, Huang PI, Chang YL, et al. Cucurbitacin I inhibitstumorigenic ability and enhances radiochemosensitivity in nonsmallcell lung caner-derived CDl33-positive cells[J], Cancer, 2011,117(13):2970-2985.

引证文献5

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部