影响胃癌腹腔脱落癌细胞阳性率的临床病理因素分析

The relationship between exfoliative cancer cells in peritoneal cavity of patients with gastric cancer and cllnicopathologieal factors

目的探讨胃癌患者腹腔脱落癌细胞阳性率与临床病理因素之间的关系。方法回顾性分析行胃癌手术的100例患者，开腹后取腹腔冲洗液500mL，检测腹腔脱落癌细胞的阳性率，分析腹腔脱落癌细胞阳性率与临床病理因素之间的关系。结果100例胃癌患者腹腔冲洗液中检测到癌细胞20例，阳性率20％。单因素分析显示，患者年龄、肿瘤大小、肿瘤侵犯深度、组织学分型是影响腹腔脱落癌细胞阳性率的危险因素；多因素Logistic回归分析显示，肿瘤侵犯深度、组织学分型是影响腹腔脱落癌细胞阳性率的独立危险因素。结论腹腔脱落癌细胞是胃癌病人发生腹膜转移的重要因素，其I临床病理特征影响腹腔脱落癌细胞阳性率。

Objective The aim was to investigate the relationship between the positive rate of exfoliative cancer cells of gastric cancer and clinicopathological factors. Methods We reviewed the records of 100 patients diagnosed with gastric carcinoma who were resected surgically. In order to test the positive rate of peritoneal free cancer cells, peritoneal washes （500 mL）were obtained after laparotomy. Then we investigated the relationship between positive rate of peritoneal free cancer cells of gastric cancer and clinicopathological features. Results Free cancer cells of peritoneal washes were in 20 patients, the positive rate was 20%. Univariate analysis showed that age,tumor size,depth on invasion and histology were risk factors for the positive rate of peritoneal free cancer cells. Multivariate analysis showed depth on invasion, histology were independent factors for the positive rate of peritoneal free cancer cells. Conclusion Peritoneal free cells is the important factor of developing peritoneal metastasis,and the clinicopathological factors affect the positive rate of peritoneal free cancer cells of gastric cancer patients.