对低危前列腺癌治疗策略的再认识及思考

Reconsideration and Thinking of Therapeutic Strategies in Low-risk Prostate Cancer

前列腺癌被认为是老年男性中最常见的恶性肿瘤。近年来,PSA筛查技术的广泛使用提高了前列腺癌的检出率。但许多低危的非致命性的前列腺癌患者却承受着过度治疗所带来的毒副反应风险。作者就当前用于减少低危前列腺癌过度治疗的新策略进行描述,如观察等待和主动监测策略,并指出癌症的过度治疗是很普遍的现象。未来需要发展更多的对恶性肿瘤进行最优治疗的策略。

The prostate cancer（Pca） is considered as a most common malignant tumor of older men. In recent years, the ad- vent of widespread PSA screening has increased positive detection rate of PCa. However,many patients with low risk, non --threatening cancer are exposed to the risk of significant side effects from over--treatment. The author describes current new strategies, Watchful Waiting and Active Surveillance,for decreasing the over--treatment of low risk PCa,and points out that the phenomenon of cancer over--treatment is a general one in oneology. More strategies need to be developed for the appropriate treatment of other cancer in future.