丹红注射液对不稳定型心绞痛患者血管内皮功能及炎症因子的影响

Effects of Danhong Injection on Vascular Endothelial Function and Inflammatory Factors in Patients with Unstable Angina Pectoris

目的探讨丹红注射液对不稳定型心绞痛(UAP)患者血管内皮功能相关因子、炎症因子水平的影响。方法 UAP患者72例,随机分为治疗组和对照组各36例。对照组给予常规药物治疗;治疗组在常规药物基础上给予丹红注射液30 mL+0.9%氯化钠溶液250 mL,静脉滴注,qd。两组疗程均为2周。检测治疗前后血清内皮素-1(ET-1)、一氧化氮(NO)、超敏C反应蛋白(hs-CRP)、凝血因子Ⅰ(Fg)、肿瘤坏死因子-α(TNF-α)水平的变化。结果治疗后治疗组血清ET-1、hs-CRP、Fg及TNF-α水平较对照组下降更为显著(P<0.05),血清NO水平则较对照组升高更为显著(P<0.05)。结论丹红注射液可有效降低UAP患者血清ET-1、hs-CRP、Fg及TNF-α水平水平,升高血清NO水平,具有抑制炎症因子的表达、改善血管内皮功能的作用。

Objective To study the effect of danhong injection on vascular endothelial function related factors and inflammation factors in patients with unstable angina pectoris（UAP）. Methods 72 patients with UAP were randomly divided into two groups：treatment group（n=36） and control group（n=36）.The control group was given with the conventional therapy,and treatment group was treated with intravenous drip of danhong injection（30 mL danhong injection added into 250 mL 0.9% sodium chloride solution,once a day） for 2 weeks besides the conventional therapy.The level of serum ET-1,NO,hs-CRP,Fg and TNF-α were tested before and after treatment. Results The serum ET-1,hs-CRP,Fg and TNF-α levels in the treatment group were obviously lower than those in the control group（P0.05）,and the level of NO was significantly increased compared with that in the control（P0.05）. Conclusion Danhong injection decreases the level of serum ET-1,hs-CRP,Fg and TNF-α and elevate serum NO,which inhibiting inflammation factors expression and improving the endothelial function of the patients with UAP.