高抗素对精神分裂症幻觉妄想的疗效观察

Efficacy of clopenthixol in treating delusions and hallucinations in schizophrenia

目的： 探索高抗素 （ｃｌｏｐｅｎｔｈｉｘｏｌ） 治疗精神分裂症幻觉妄想的效果。 方法： 随机选择符合 Ｃ Ｃ Ｍ Ｄ２ Ｒ诊断标准的偏执型精神分裂症患者住院病例１４ 例、门诊病例１６ 例， 合计３０ 例。采用保留病人的原有抗精神病药物半量联合高抗素的治疗方法， ３ 个月为一个疗程。 结果： 经过一个疗程的观察， 经联合应用高抗素后２８ 例具有幻觉的病例中２２ 例显效， 幻觉消失率达７８６％ ， ６ 例无效； ２４例具有妄想的病例中 １６ 例显效， 妄想消失率为６６６％ ， ８ 例无效。其中真性幻觉的疗效比伪幻觉好， 在妄想中继发性妄想比原发性妄想的疗效好。 结论： 高抗素是继奋乃静的抗幻觉， 氯丙嗪的抗思维障碍之后的又一新型抗幻觉妄想药物。

Objective:To study the efficacy of clopenthixol in control delusions and hallucinations in schizophrenia. Method:Thirty subjects (14 inpatients & 16 outpatients) with diagnosis of schizophrenia (paranoid type) according to CCMD 2 R were randomly recruited from in and out patients.They were maintained on half dose of their original psychotropics together with therapeutic dose of clopenthixol for three months.The clinical features were monitored before and for three months with the new combination regime. Results:Clopenthixol was effective in 22 out of 28 (78 6%)cases with hallucination and 16 out of 24 (66 6%) cases with delusion.Genuine hallucination and secondary delusion responded better than pseudohallucination and primary delusion. Conclusion:Clopenthixol is effective in controlling psychotic symptoms of schizophrenia.