氯丙咪嗪与舒必利辅助治疗精神分裂症阴性症状的对照研究

A controlled trial comparing chlorimipramine and sulpiride as adjunct to clozapine in the treatment of negative symptoms of schizophrenia

目的： 比较氯丙咪嗪、舒必利辅助治疗精神分裂症阴性症状的效果。 方法： 使用氯丙咪嗪、舒必利分别作为氯氮平的辅助用药与单用氯氮平对８８ 例以阴性症状为主的精神分裂症病人进行对照研究； 以简明精神病评定量表、阴性症状量表和副反应量表进行评定。 结果： 合并氯丙咪嗪组、舒必利组及单用氯氮平组对阴性症状的治疗显效率分别为６９％ 、３１％ 、１３３３％ 。 结论： 氯氮平合并氯丙咪嗪治疗能有效地改善精神分裂症的阴性症状。

Objective:To compare chlorimipramine and sulpiride as adjunct in the treatment of negative symptoms in schizophrenic patients. Method:88 inpatients with diagnosis of chronic schizophrenia with negative symptoms were treated clozapine alone,clozapine/chlorimipramine combined,or clozapine/sulpiride combined regime.Clinical progress was monitored with BPRS,SANS and TESS. Results:The response rate for negative symptoms in the clozapine/chlorimipramine combined, clozapine/sulpiride combined and clozapine alone group were 69%,31%,and 13 3% respectively. Conclusion:Negative symptoms of schizophrenia could be improved effectively with clozapine combined with chlorimipramine.